Brandon is a gifted lead guitarist/vocalist and has performed at major venues in Chicago, New Orleans, Houston, Dallas, & Denver. He has opened or performed with these major artists:

B.B. King, Fabulous Thunderbirds, Joe Walsh, Neville Brothers, Kenny Wayne Shepherd, George Thorogood, Smokin’ Joe Kubek w/Bnois King, Reverend Horton Heat, Joan Jett, Doobie Brothers, Chicago, Little Feat, Big Head Todd & the Monsters, Robert Randolph, .38 Special, Edgar Winter, Georgia Satellites, Son Seals, Kenny Neal, Eddy Clearwater, Blood, Sweat & Tears, Roomful of Blues, Russell Jackson (former bassist for B.B. King), Sista Monica, Jimmy D. Lane, Jimmy Thackery, Kelly Hunt, Indigenous, Randy McAllister & Chris Duarte.

On July 28, 2012 Brandon Sprague Blues Band performed at the Sioux Falls, S.D. JazzFest on Saturday, which included headliner Joe Walsh. The band .38 Special recently met Brandon at his club gig in Deadwood and asked “Where in the hell have you been!” They proceeded to jam with him the rest of the night at the club.